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Delivering the Added Dimension in Drug Discovery Services

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Soy Protein-Based Hydrogel under Microwave-Induced Grafting of Acrylic Acid and 4‑(4-Hydroxyphenyl)butanoic Acid.

 Authors: Saloni Mehra, Safiya Nisar, Sonal Chauhan, Virender Singh, and Sunita Rattan 

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An in vitro model of hepatic steatosis using lipid loaded induced pluripotent stem cell derived hepatocyte like cells

 Authors: Hiraganahalli Bhaskar Deepak, Nellikalaya Shreekrishna, Zaheerbasha Sameermahmood, Niranjan Naranapur Anand, Raghotham Hulgi, Juluri Suresh, Sonal Khare, Saravanakumar Dhakshinamoorthy 

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A CRO that supports drug discovery ideas and passion – Jubilant Biosys

BIO Impact Interview June 2020 with Dr Takeshi Yura

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PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits

Authors: Feng Yi, Nirvan Rouzbeh, Kasper B. Hansen, Yuelian Xu, Christopher M. Fanger, Earl Gordon, Kathy Paschetto, Frank S. Menniti,∗, Robert A. Volkmann

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Modulating inhibitory response control through potentiation of GluN2D subunit-containing NMDA receptors

Authors: Patrick M. Callahan, Alvin V. Terry Jr., Frederick R. Nelson, Robert A. Volkmann, A.B. Vinod, Mohd Zainuddin, Frank S. Menniti

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Incurred sample reanalysis of cefuroxime in rabbit ocular tissues – A case study

Authors: Bhavesh Babulal Gabani, Vinay Kiran, Shuvranshu Praharaj, Nuggehally R. Srinivas, Ramesh Mullangi

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Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague–Dawley rats

Authors: Bhavesh Babulal Gabani, Umesh Todmal, Neeraj Kumar Saini, Vinod A. Balakrishna, Suresh P. Sulochana, Ashok Timmapuram, Mohd Zainuddin, Narayanan Balaji, Praharaj Shuvranshu, Nuggehally R. Srinivas & Ramesh Mullangi

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Uptake and pharmacokinetics of cefuroxime in rabbits after intravitreal, intracameral, and topical dosing: relevance to human ocular injection of cefuroxime

Authors: Ravi Kumar Jairam, Sadanand R. Mallurwar, Bhavesh B. Gabani, Ashok Zakkula, Vinay Kiran, Sreekanth Dittakavi, Suresh P. Sulochana, Zainuddin Mohd, Nuggehally R. Srinivas and Ramesh Mullangi

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ACR/ARP Abstract: Novel, Selective, Orally Active PAD4 Inhibitors for the Treatment of Autoimmune Disorders

Authors: Santosh Vishwakarma, Gurulingappa Hallur, Himanshu Agrawal, Sharad Singh, Annasaheb Kalange, Seema Chikkur Gangadhar, Shuvranshu PraharaJ, Nafees Ahmad Quresh, Srikanth Kanagal Gopinath, Krishnakumar V, Sameer Mahmood, Rudresh G, Mohd Zainuddin, Rajendra Kristam, Ishtiyaque Ahmad, Ramachandraiah Gosu, Purra Buchi Reddy, N V S K Rao, Saloni Mehra, Jeyaraj D A, Takeshi Yura, Saravanakumar dhakshinamoorthy, Sriram Rajagopal, Dhanalakshmi Sivanandhan and Sridharan Rajagopal

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White Paper: AI ML Pilot Studies on Drug Repositioning and Drug Target Identification

Authors: J.Sooriya Kumar, Maharnob Sarkar, Parimala S Devi

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High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Authors: Rocco L. Policarpo, Ludovic Decultot, Elizabeth May, Petr Kuzmic, Samuel Carlson, Danny Huang, Vincent Chu, Brandon A. Wright, Saravanakumar Dhakshinamoorthy, Aimo Kannt, Shilpa Rani, Sreekanth Dittakavi, Joseph D. Panarese, Rachelle Gaudet and Matthew D. Shair

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Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics based on Normalizing Time Course Profiles

Authors: Ravi Kumar Jairam, Sadanand Rangnathrao Mallurwar, Suresh P. Sulochana, Devaraj V. Chandrasekhar, Umesh Todmal, Ravi Kanth Bhamidipati, Wolfgang Richter, Nuggehally R. Srinivas and Ramesh Mullangi

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Design and Synthesis of a Novel Series of Cyanoindole Derivatives as Potent γ-Secretase Modulators

Authors: François P. Bischoff, Adriana Ingrid Velter, Garrett Minne, Serge Pieters, Didier Berthelot, Michel De Cleyn, Harrie J.M. Gijsen, Gregor Macdonald, Michel Surkyn, Sven Van Brandt, Yves Van Roosbroeck, Chiara Zavattaro, Marc Mercken, Nigel Austin, Deborah Dhuyvetter, Herman Borghys, Ishtiyaque Ahmad, Swapan Kumar Samanta

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Protection of Beta Cell Mass From Diabetogenic Condition Induced Apoptosis By The Inhibition Of Mammalian Ste20-like Protein Kinase 1 (MST1)

Authors: Zaheerbasha Sameermahmood, Dhanalakshmi Sivanandhan, Biswajit Kalita, Sowmya Ramaiah, Amir Siddiqui, Bharat R. Zope, Sanjay V. Kadnur, Madhuri Kanavalli, Krishnakumar V, Srinivasan Swaminathan, Rudresh G, Sunil Mohire, Raghunadha R. Burri, Rajendra Kristam, Jeyaraj D A, Sriram Rajagopal, Saravanakumar Dhakshinamoorthy

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Novel Small Molecule KV7 Openers for the Treatment of Epilepsy

Authors: Mark A. Seefeld, Hong Lin, Joerg Holenz, Dave Downie, Brian Donovan, Tingting Fu, Kishore Pasikanti, Wei Zhen, Matthew Cato, Khuram W. Chaudhary, Pat Brady, Tania Bakshi, Dwight Morrow, Sridharan Rajagopal, Swapan Kumar Samanta, Naveena Madhyastha, Bharathi Mohan Kuppusamy, Robert W. Dougherty, Ravi Bhamidipati, Zainuddin Mohd, Guy A. Higgins, Mark Chapman, Céline Rouget, Philippe Lluel, Yasuji Matsuoka

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A Novel Dried Blood Spot LC–MS/MS Method for the Quantification of Apalutamide in Mouse Whole Blood

Journal: Biomedical Chromatography

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Determination of Tofacitinib in Mice Whole Blood on Dried Blood Spots Using LC–ESI–MS/MS

Authors: Abhishek Dixit, Sadanand Rangnathrao Mallurwar, Suresh P Sulochana, Mohd Zainuddin, Ramesh Mullangi

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Targeting HIF-2α as Therapy for Advanced Cancers

Authors: Thanabal Murugesan, Gurukumari Rajajeyabalachandran, Swetha Kumar, Shruthi Nagaraju, Sooriya Kumar Jegatheesan

Journal: Drug Discovery Today, Volume 23, Number 7, July 2018.

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Across Geographies – From the Lens of a Project Manager from a Healthcare CRO

Author: Bhuvaneswari Jayaraman

Presented at: Project Management Practitioners Conference 2018, Bangalore

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Synthetic Analogues of the Parasitic Worm Product ES-62 Reduce Disease Development in In Vivo Models of Lung Fibrosis

Authors: Colin J.Sucklinga, SambuddhoMukherjee, Abedawn .Khalafa, Ashwini Narayan, Fraser J.Scott, Sonal Khare, Saravanakumar Dhakshinamoorthy, Margaret M.Harnett, William Harnett

Journal: Acta Tropica 185 (2018) 212–218

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Novel, Heterocyclic Small Molecule Inhibitors of PD-1/PD-L1 Pathway

Authors: Shivani Garapaty, Dhanalakshmi Sivanandhan, Chandregowda Venkateshappa, Guru Pavan Kumar Seerapu, Reshma Das, Pradeep Nagaraj, Ronodip Kar, Anuj Kumar Singh, Venkatesha Ashokakumar Venkatasubbaiah, Rama Kishore VP Putta, Muralidhar Pendyala, Girisha Lokesh, Hari Madaka, Harikrishna Reddy Thummuru, Shikas AP, Pratheeksha Anchan, Prathima Bhat, Rudresha G., Mohd. Zainuddin, Krishnakumar V, Ramachandraiah Gosu, Rajendra Kristam, Jeyaraj DA, Sriram Rajagopal

Journal/Conference: Poster presented at “ AACR Annual Meeting 2018”

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Novel Dual Small Molecule Inhibitor Targeting LSD1 and HDAC6/8

Authors: S. Dhanalakshmi, S. Rajagopal, S. Nair, C. Gajendran, D. Ghosh, P. Nagaraj, A. K. Singh, S. J. Tantry, P. Dewang, M. Hallur, M. Kannan, K. C Srinatha, D.Kuntrapaku, M. Dilipkumar, R. Sharma, S. Meghashree, D. P. Kumar, S. Ingle, G. Rudresh, M. Zainuddin, A. B. Vinod, V. Krishnakumar, S. Rajagopal

Journal/Conference: Poster presented at “ AACR Annual Meeting 2018”

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Novel, Small Molecule PRMT5 Inhibitors for Treatment of Cancer

Authors: Shivani Garapaty, Dhanalakshmi Sivanandhan, Saravanan Vadivelu, Guru Pavan Kumar Seerapu, Reshmam Das, Anuj Kumar Singh, Ronodip Kar, Venkatesha Ashokakumar Venkatasubbaiah, Tamizharasan Natarajan, Indu N Swamy, Nagendra Nagaraju, Subramaniam Kanagaraj, Sayantani Sarkar, Jagdish D Tibhe, Rudresha G, Mohd Zainuddin, Raghunadha Reddy Burri, Manish Kumar Thakur, Saravanan Kandan, Swarnakumari V, Raghunadha Burri, Sridharan Rajagopal, Sriram Rajagopal

Journal/Conference: Poster presented at “ AACR Annual Meeting 2018”

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Novel Dual Inhibitor of LSD1/HDAC1 for Treatment of Cancer

Authors: D. Sivanandhan, S. Rajagopal, S. Nair, C. Gajendran, P. Nagaraj, D. Ghosh, A.K. Singh, R. Kar, P. K. Parikh, S.J. Tantry, P. Dewang, M. Hallur, M. Kannan, K. C Srinatha, D. Kuntrapaku, M. Dilipkumar, R. Sharma, S. Meghashree, D.P. Kumar, G. Rudresh, M. Zainuddin, S. Garapaty, V. A. Venkatasubbiah, V. Krishnakumar, S. Rajagopal

Journal/Conference: Poster presented at “ AACR Annual Meeting 2018”

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A Small Molecule Inhibitor of Nicotinamide N-methyltransferase for the Treatment of Metabolic Disorders

Authors: Aimo Kannt, Sridharan Rajagopal , Sanjay Venkatachalapathi Kadnur2, Juluri Suresh, Ravi Kanth Bhamidipati, Srinivasan Swaminathan, Mahanandeesha Siddappa Hallur, Rajendra Kristam, Ralf Elvert, Jörg Czech, Anja Pfenninger, Christine Rudolph, Herman Schreuder, Devaraj Venkatapura Chandrasekar, Vishal Subhash Mane, Swarnakumari Birudukota, Shama Shaik, Bharat Ravindra Zope, Raghunadha Reddy Burri, Niranjan Naranapura Anand, Manish Kumar Thakur, Manvi Singh, Reejuana Parveen, Saravanan Kandan, Ramesh Mullangi, Takeshi Yura, Ramachandraiah Gosu, Sven Ruf & Saravanakumar Dhakshinamoorthy

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PLK4: A Link between Centriole Biogenesis and Cancer

Authors: Radhika Radha Maniswami, Seema Prashanth, Archana Venkataramana Karanth, Sindhu Koushik, Hemalatha Govindaraj, Ramesh Mullangi, Sriram Rajagopal & Sooriya Kumar Jegatheesan

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Crystal Structures of Monkey and Mouse Nicotinamide N-methyltransferase (NNMT) bound with End Product, 1-methyl Nicotinamide

Authors: Swaminathan S, Birudukota S, Thakur MK, Parveen R, Kandan S, Juluri S, Shaik S, Anand NN, Burri RR, Kristam R, Hallur MS, Rajagopal S, Schreuder H, Langer T, Rudolph C, Ruf S, Dhakshinamoorthy S, Gosu R, Kannt A

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PAD4: Pathophysiology, Current Therapeutics and Future Perspective in Rheumatoid Arthritis

Authors: Sindhu Koushik, Nivedita Joshi, Shruthi Nagaraju, Sameer Mahmood, Krishna Mudeenahally, Ramya Padmavathy, Sooriya Kumar Jegatheesan, Ramesh Mullangi and Sriram Rajagopal

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Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution

Authors: Manish Kumar Thakur, Swarnakumari Bridukota, Srinivasan Swaminathan, Sivarama Krishna Battula, Sarvanan Vadivelu, Rajiv Tyagi and Ramchandraiah Gosu

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Emerging Role of SETDB1 as a Therapeutic Target

Authors: Archana Venkataramana Karanth, Radhika Radha Maniswami, Seema Prashanth, Hemalatha Govindaraj, Ramya Padmavathy, Sooriya Kumar Jegatheesan, Ramesh Mullangi and Sriram Rajagopal

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