Chemistry Services

Medicinal Chemistry Services

The Jubilant Biosys chemistry department offers the following MedChem services:

• Design and synthesis of novel chemical entities in drug discovery programs such as target to hit, hit to lead and lead optimization SAR studies
• Designing novel chemical entities (in collaboration with Silico Molecular Modelling Group)
• Biological profiling of the designed compounds (In collaboration with our in-vitro and in-vivo biology groups)
• Structural directed design in drug discovery program (in collaboration with the X-ray Crystallography Group)
• IPR evaluation of the scaffolds

The Jubilant Biosys team responsible for implementing medicinal chemistry services comprises knowledgeable medicinal chemists who are not only well-trained in one discipline but have experience in bringing all the elements together into one focused drug discovery program.

Working together with our Structural Biology and Computational Chemistry groups, the MedChem team is well versed in interpreting biological data to optimize compounds to meet all the requirements of a viable clinical candidate.

This pharmaceutical chemistry team:

• Has a track record of delivering clinical candidates starting from, for example, in-silico screening hits, in a short time
• Has expertise in every step of the drug discovery process, starting from early-stage target identification, through hit identification, hit to lead optimization and then lead optimization, leading to the identification of clinical candidates
• Comprises of approximately 100 research chemists

The medicinal chemistry team has a performance history of solving the various problems often encountered during the optimization discovery process, such as potency, selectivity, off-target activity, physicochemical properties, DMPK related issues, safety-related issues and such. They have accumulated expertise in various therapeutic areas over the years, including, but not limited to, oncology, metabolic disorders, inflammation and CNS.

Click the links below to explore our Medicinal Chemistry Services:

Chemists at our contract research orgnization have worked on more than 85 integrated drug discovery programs yielding many pre-clinical candidates, out of which numerous compounds have advanced into the clinic. The group also has strong organic synthesis capabilities and can offer pharmaceutical chemistry services independently or as part of an integrated program.