Jubilant Biosys

Delivering the Added Dimension in Drug Discovery Services

Analytical Chemistry

The analytical team provides support to discovery and process chemistry groups as an integrated service or a stand-alone option for our customers.

Purification

  • Isolation, purification and characterization of compounds from milligrams to multi-grams (PDA, MS and ELSD)
  • Chiral purification milligrams to multi-kilograms (SFC)
  • High throughput purification services (PDA and MS Directed)

Structure Elucidation

  • Structure elucidation of new chemical entities (NCEs) by mass spectrometry, NMR (1H, 13C, 19F, 11B, 15N), IR and UV-Visible spectrophotometry
  • Higher NMR experiments like NOESY, HMBC, HMQC and others
  • MS, MS-MS, LCMS

Solid State Characterization

  • Solid state analysis (DSC, TGA and XRPD)
  • Crystalization studies
  • Polymorph screening
  • Polymorph characterization

Physicochemical Study

  • Melting point
  • Solubility
  • pKa
  • Log P determination
  • Optical rotation
  • NMR/LCMS/MS/HPLC
  • Elemental analysis
  • Solid state analysis (DSC, TGA and XRPD)

Impurity Profiling

  • Isolation of impurity
  • Structure elucidation
  • Impurity synthesis

Analytical Method Development/Validation for CMC

  • HPLC-UV/PDA/ELSD/Chiral methods for in-process, intermediates and NCE API
  • Residual solvent by GC, GC-HSMS – as per ICH Q3
  • Impurities/Assay by HPLC/UPLC – as per ICH Q3
  • Elemental Impurities/ (ICP-OES/MS) – as per ICH Q3D
  • Forced degradation study
  • ICH compliant stability studies – as per ICH Q1A