Analytical Chemistry Services
Jubilant Biosys offers its customers a complete range of analytical chemistry services of the highest quality and fast-track delivery. Understanding each project’s unique requirements, the quantitative and qualitative analysis, structural uniqueness, purification, and chemical characterization are performed as needed using advanced technologies.
The analytical team provides support to discovery and process chemistry groups as an integrated service or a stand-alone option for our customers. Our unique approach allows us to identify and evaluate the chemical in our analytical testing laboratories rapidly and effectively communicate the resulting data to help our customers understand the product’s chemistry.
Purification
- Isolation, purification and characterization of compounds from milligrams to multi-grams (PDA, MS and ELSD)
- Chiral purification milligrams to multi-kilograms (SFC)
- High throughput purification services (PDA and MS Directed)
Structure Elucidation
- Structure elucidation of new chemical entities (NCEs) by mass spectrometry, NMR (1H, 13C, 19F, 11B, 15N), IR and UV-Visible spectrophotometry
- Higher NMR experiments like NOESY, HMBC, HMQC and others
- MS, MS-MS, LCMS
Solid State Characterization
- Solid state analysis (DSC, TGA and XRPD)
- Crystalization studies
- Polymorph screening
- Polymorph characterization
Physicochemical Study
- Melting point
- Solubility
- pKa
- Log P determination
- Optical rotation
- NMR/LCMS/MS/HPLC
- Elemental analysis
- Solid state analysis (DSC, TGA and XRPD)
Impurity Profiling
- Isolation of impurity
- Structure elucidation
- Impurity synthesis
Analytical Method Development/Validation for CMC
- HPLC-UV/PDA/ELSD/Chiral methods for in-process, intermediates and NCE API
- Residual solvent by GC, GC-HSMS – as per ICH Q3
- Impurities/Assay by HPLC/UPLC – as per ICH Q3
- Elemental Impurities/ (ICP-OES/MS) – as per ICH Q3D
- Forced degradation study
- ICH compliant stability studies – as per ICH Q1A
