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Delivering the Added Dimension in Drug Discovery Services

Advancing small molecule program from Hit to Candidate with our 4D promise” Webinar

Case Study: Small molecule inhibitors of NNMT for treatment of metabolic disorders

Tuesday, 8th December 2020

Webinar Description:

Case Study: The project was started with the aim to identify lead series and lead compounds for the inhibition of NNMT to treat metabolic disorders.  The project team faced numerous challenges such as a moderate ADME profile of the starting compounds, establishing biochemical assays for the target and several selectivity assays, establishing target engagement and efficacy models and such. In this webinar, we will discuss the strategic workflows to overcome such challenges, our project journey and swift successful delivery of a lead series and lead compounds. 

Our 4D focused project approach, attributed premier importance to scientific value addition, driving scientific insights about metabolic therapeutic domain – pharmacological benefits in vivo.  In addition, we offer a platform for all attendants to share their best practices, experience and bring in their queries.

Takeaways:

Speakers:

Dr Takeshi Yura

Dr. Takeshi Yura
Vice President – Medicinal Chemistry and Site Head

Dr. Yura has more than 28 years’ experience in Medicinal and Organic Chemistry, beginning his career with Tanabe Seiyaku Tokyo Research Center where he worked as Research Chemist. Post this he was associated with Ciba Geigy Japan (Takarazuka Research Center), Bayer Yakuhin (Research Center Kyoto), Pfizer Japan (Pfizer Global Research and Development Nagoya Laboratories) and Dishman Japan Ltd.


Before joining us he worked with Albany Molecular Research Singapore Research Centre, Pte. Ltd, as Vice President, Discovery and Development Services for Asia and General Manager for Singapore Research Centre. At AMRI he was responsible for, AMRI Singapore Research Centre’s chemistry and biology operations and AMRI Hyderabad Research Centre.

Dr. Yura was awarded the PhD degree in Chemistry from University of Tokyo, Japan. He has completed his Executive MBA program from Temple University, Tokyo, Japan.

He has many papers to his credit in International Journals apart from Abstracts and Posters. He has 15 patents to his credit.

Moderator:

Saurabh Kapure

Saurabh Kapure
Vice President – Business Development (US & APAC)

Saurabh has over 18 years of experience in corporate and international business development in pharmaceutical and drug discovery contract research organizations, marketing (product/brand management), strategic planning, alliance and process management. He has worked across various geographies like Europe, North America and Asia wherein he created and built businesses from scratch. His experience is spread across multiple Indian pharma cos including Torrent Pharma, Piramal Enterprises and Dr. Reddy’s Laboratories where he worked in various businesses around branded generics and Drug Discovery service providers including Aurigene Discovery, AMRI Global and Panacea Biotech both in managerial and leadership roles.