| In Vitro Biology |
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| The In Vitro Biology group at Jubilant has state of the art infrastructure and the expertise to perform a variety of biochemical and cellular assays against most target classes, including enzymes, GPCR’s, ion channels (e-phys), NHR’s and transporters. |
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The department is equipped with state-of-the-art facilities to enable these assays, including sophisticated liquid-handling, compound-handling and assay-detection systems. With a high ratio of PhD scientists, the group also has the expertise to take on target validation and mechanism studies.
- Biochemical & cell based assay development & validation
- State-of-the-art instrumentation for screening
- Fully automated compound management system
- Statistical support with IT enabled screening tools
- Advanced algorithms for data processing and quality evaluation
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| Biology Assay Development & Validation |
| Biochemical and Cell Based Assays |
- ELISA
- Radioactive Binding Assays
- FRET
- HTRF
- Kinetic Assays
- Filter Binding Assays
- Scintillation Proximity Assays
- Calcium dye based FLIPR and FDSS assays
- hERG Assays
- Cell based ELISA
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- Whole Blood Assays
- Cell Viability (LDH, MTT, Alamar Blue)
- Flow Cytometry Assays
- Western Blotting and In Cell ELISA
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| Target or Pathway Specific Assay |
- DiscoverX Platform, including beta-arrestin assays (PathHunter and PathFinder Assays)
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| Phenotypic Screens |
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| Assay Technologies |
- Radiometric- SPA, Filter binding, Flash plate
- Fluorescent- FP, FRET, HTRF, TRF, DELFIA, Lance
- Luminescent Alpha screen
- Luminescent aequorin assays
- HT planar patch clamp electrophysiology
- HT atomic absorption spectroscopy
- Meso Scale Discovery platform
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