Ion channels constitute a large and diverse group of membrane proteins that functions as electrical signal transducers, and they govern the electrical properties of all living cells. The function or dysfunction of ion channels can have a strong impact on cellular function and cellular signaling. Ion channels are required in multiple normal physiological processes, such as muscle contraction and neuronal signal transmission. Several diseases are related to dysfunctional ion channels : cardiac arrhythmia, diabetes, hypertension, angina pectoris and epilepsy.

Drugs targeting ion channels generate over 6 billion dollars in sales per annum. According to FDA, the number of new approved drugs targeting ion channels are higher than that of drugs targeting proteases, polymerases and reverse transcriptases .

Product Profile:

Jubilant Biosys is building a comprehensive small molecule ligand centric database on ION CHANNEL. The database is the integrated chemical and biological information of known ION CHANNEL from Patents and Journals.

	Intended to cover over 10 000 ligands
	Informations would be captured from the estimated 300 scientific journals and 600 patents.
	Covers 4 Ion Channel classes
	The current size of the database is around 34000 records

	Intended to cover over 10 000 ligands
	Informations would be captured from the estimated 300 scientific journals and 600 patents.
	Covers 4 Ion Channel classes
	The current size of the database is around 34000 records

The Database contains three floating forms:

	General
	Invitro Assays
	Other assays

General form – Key parameters

	2D chemical structure
	IUPAC name
	Chiral
	Mechanism of action
	Localization
	Binding Site
	Critical motifs
	Signal Transduction
	Therapeutic indication
	Structural information
	Bibliographic reference

Invitro Assays, Electrophysiology Assays and Invivo Assays – Key parameters

	Bioassay
	Target
	Source
	Type
	Value status
	Value
	SD
	Unit