Physicochemical screens are extensively used in drug discovery to provide an early understanding of key properties that affect ADME. They also ensure that discovery experiments are planned and interpreted correctly. Key physicochemical properties like lipophilicity, low solubility in dimethyl sulfoxide, aqueous solubility, aggregation and nonspecific binding to proteins and permeability across artificial membranes are very important in early drug discovery and candidates selection.

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• Aqueous solubility at different pH
• Log D