|
|
| Biotransformation |
JBL offers a comprehensive and integrated biotransformation
services to support discovery research and development of
new drug candidates. Through careful metabolite
identification and profiling, we can discover metabolic
pathways for new drug candidates.
Services
-
In vitro phase I and phase II metabolite
identification and profiling in hepatocytes and liver
microsomes (animals and humans).
-
In vivo metabolite identification and profiling in rodents
(plasma and urine).
-
In vitro and In vivo metabolic ‘Hotspot’
identification.
Capabilities
-
HPLC (with UV, PDA and fluorescence) and API4000
Q-Trap MS for metabolite identification and profiling.
-
Light Sight software to aid data interpretation.
-
Synthetic chemistry for synthesis of metabolites,
reference standards and internal standards.
-
Data interpretation by experienced metabolomic
scientists.
-
Access to NMR – 1D, 1H, 13C, 19F, 31P (up to 800MHz).
-
Access to NMR – 2D COSY, NOESY, 13C-1H correlation
|
| |
|
|
|
|
