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The MolSignTM database
can be used to
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Identify drug targets associated
with a disease |
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Compare diseased and normal states |
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Discover modifications affecting a
disease pathology |
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Understand the expression profiles
of specific molecules |
Product Profile
The MolSignTM database is a
comprehensive collection of disease marker
information from literature and peer
reviewed articles (1998-2005).
5750 potential biomarkers spanning
three
major disease areas
Cancer:
5367 markers across 31 cancer
types
Arthritis: 636 markers across
rheumatoid, juvenile and osteoarthritis
Diabetes: 421 markers covering type
II
diabetes
Over 60,000 records and updated
every
quarter.
Key
Functionality
The MolSignTM database is manually curated and quality checked, having
information from over 3000 articles
covering
Expression studies:
Gene/Protein
regulation and expression
levels
Mutation: Polymorphism,
chromosomal
aberrations, including
loss of
heterozygosity and their
effect
Epigenetic and post-translational
modifications affecting function
Biomolecular interactions and the
role of
inhibitors
Biomolecules covered include genes
& splice variants, proteins & isoforms,
metabolites, hormones, carbohydrates and
lipids.
Strict adherence to standard nomenclature
and controlled vocabulary makes it easy to
search. The database can be queried directly
by marker, disease and be combined with any
of the other fields available through the
interface. The reports are conveniently
linked to 19 public domain databases.
Technical Specification
The MolSignTM
is a highly robust web-based Java
application (requires Java Runtime
Environment (JRE) 1.4.2) with Oracle 9i as
the backend.
Register here for
product demo
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